Malignant Catarrhal Fever
نویسنده
چکیده
MCF is defined by the recognition of characteristic lymphoid cell accumulations in non-lymphoid organs, vasculitis, and T-lymphocyte hyperplasia in lymphoid organs, and can be caused by either of two gamma-herpesviruses. The alcelaphine herpesvirus-1 (AIHV-1), the natural host of which, the wildebeest, is infected inapparently, causes the disease in cattle in regions of Africa and various ruminant species in zoos worldwide. Ovine herpesvirus-2 (OvHV-2), which is prevalent in all domestic sheep as a subclinical infection, is the cause of MCF in other ruminants in most regions of the world. This form of the disease has formerly been referred to as sheep-associated MCF. In both forms of the disease, animals with clinical disease are not a source of infection because virus is excreted only by the natural hosts, wildebeest and sheep.
منابع مشابه
Malignant catarrhal fever in pastoral Maasai herds caused by wildebeest associated alcelaphine herpesvirus-1: An outbreak report
An outbreak of malignant catarrhal fever (MCF), a fatal viral disease in indigenous Tanzanian shorthorn zebu in Ngorongoro district of Tanzania during the period of June 2004 has been described. The disease was diagnosed by clinical, post mortem findings and the virus was identified using molecular characterization study. The history and clinical features included pyrexia, cornel opacity, nasal...
متن کاملAn outbreak of porcine malignant catarrhal fever in a farrow-to-finish swine farm in the United States
Malignant catarrhal fever is a sporadic, often fatal viral disease affecting multiple species, including swine. Ovine herpesvirus type 2 (OvHV-2), the cause of sheep-associated malignant catarrhal fever, incites nonspecific clinical signs and occasional death in swine. An outbreak of malignant catarrhal fever in a farrow-to-finish swine farm in the United States was confirmed by identifying OvH...
متن کاملMalignant catarrhal fever.
Malignant catarrhal fever is briefly reviewed and recent findings are described. Initially the disease was observed as a disease of cattle in Europe where, although no cause could be identified, circumstantial evidence implicated sheep as a source of infection and it was thus designated 'sheep-associated' malignant catarrhal fever. Subsequently the disease was observed in Africa where it became...
متن کاملDevelopment of a multiplex real-time PCR for detection and differentiation of malignant catarrhal fever viruses in clinical samples.
A multiplex real-time PCR was developed using a single pair of primers and fluorescent probes specific for five malignant catarrhal fever viruses and an internal positive control. The assay was able to simultaneously detect and differentiate the viruses in clinical samples with high sensitivity (97.2%) and specificity (100%).
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